DR Systems

Face Analyzer: objective measurement of ongoing/​spontaneous pain in mice

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Description
Key features
Device
How to buy
Publications

Pain in mice is usually scored by eye, with an observer in the room, or measured with tests that need a stimulus. Face Analyzer, a patented DR System, measures changes in facial expression, such as those caused by spontaneous pain, automatically and with no one in the room.

Digital Researchers

Key features

01

Official Digital Researchers for CD-1 and C57BL/6 mice

Start with Mouse Data’s official Digital Researchers, trained on the facial expression of albino and pigmented mice.

02

Train a Digital Researcher for your study

Record two groups, baseline and post-treatment or control and treated. The Digital Researcher finds the differences by itself and applies that criterion to every new video.

03

Share Digital Researchers with collaborators

Share your Digital Researchers with your collaborators, or use the ones they share with you.

04

The same observation, every time

Wherever and whenever you record, the Digital Researcher observes in exactly the same way, so results stay comparable across studies, sites and scorers.

Our technology

Device

01

High-resolution cameras

Infrared video cameras minimize the influence of ambient lighting.

02

Proprietary hardware

Designed to encourage the mice to face the cameras.

03

Just press record

Videos are sent automatically to your account in Mouse Data Lab.

02

Proprietary hardware

Designed to encourage the mice to face the cameras.

04

Built for intensive research

Easy to decontaminate and resilient in intensive scientific settings.

How to buy

Buy or rent the device. Analyze with credit packs.

Request a quote

Buy or rent

Purchase the device, or rent it for 3, 6, 12 or 24 months to match your project.

Credit packs for analysis

Digital Researcher analyses run on one-off credit packs, valid for four years. Choose the pack that fits your study.

Enterprise plans

For pharma and CROs: plans by volume, maintenance and device replacement within three business days.

Request a quote

Tell us about your lab

We'll send you pricing for Face Analyzer and the credit packs within two business days.

We'll use your details only to answer your request. See our Privacy Policy.

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INSIGHTS

Discover our publications

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Papers
Pain Outcome Determines the Sensitivity to Peripheral Opioid Antagonism of Morphine, Ibuprofen, and Their Combination in Laparotomized Mice

Face Analyzer technology measured ongoing pain from facial expression after abdominal surgery.

Pain Outcome Determines the Sensitivity to Peripheral Opioid Antagonism of Morphine, Ibuprofen, and Their Combination in Laparotomized Mice.

Hasoun MA, Santos-Caballero M, Huerta MÁ, Robles-Funes M, Puerto-Moya A, Ruiz-Cantero MC, Cobos EJ, González-Cano R.

Pharmaceutics. 2026 Mar 21;18(3):392. doi: 10.3390/pharmaceutics18030392.

https://pmc.ncbi.nlm.nih.gov/articles/PMC13030386/
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Papers
Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities

Face Analyzer technology detected pain-like facial expressions in mice lacking TRPM8.

Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.

Cabañero D, Carter EP, González-Cano R, Cobos EJ, Fernández-Carvajal A, Ferrer-Montiel A.

J Headache Pain. 2025 Jun 23;26(1):146. doi: 10.1186/s10194-025-02082-4.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12183901/
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Papers
Minocycline Prevents the Development of Key Features of Inflammation and Pain in DSS-induced Colitis in Mice

Minocycline Prevents the Development of Key Features of Inflammation and Pain in DSS-induced Colitis in Mice.

Vezza T, Molina-Tijeras JA, González-Cano R, Rodríguez-Nogales A, García F, Gálvez J, Cobos EJ.

J Pain. 2023 Feb;24(2):304-319. doi: 10.1016/j.jpain.2022.09.016. Epub 2022 Sep 29.

https://www.jpain.org/article/S1526-5900(22)00416-3/fulltext
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Papers
Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment

Face Analyzer technology measured pain at rest from facial expression after abdominal surgery.

Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment: A study in laparotomized mice.

Santos-Caballero M, Ruiz-Cantero MC, Mayr HK, Huerta MÁ, Hasoun MA, Robles-Funes M, Puerto-Moya A, Cronin SJF, González-Cano R, Cobos EJ.

Biomed Pharmacother. 2025 Aug;189:118298. doi: 10.1016/j.biopha.2025.118298. Epub 2025 Jun 28.

https://www.sciencedirect.com/science/article/pii/S0753332225004925?via%3Dihub
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Papers
Pharmacological differences in postoperative cutaneous sensitivity, pain at rest, and movement-induced pain in laparotomized mice

Face Analyzer technology measured pain at rest from facial expression, alongside skin sensitivity and movement-induced pain.

Pharmacological differences in postoperative cutaneous sensitivity, pain at rest, and movement-induced pain in laparotomized mice.

Santos-Caballero M, Hasoun MA, Huerta MÁ, Ruiz-Cantero MC, Tejada MÁ, Robles-Funes M, Fernández-Segura E, Cañizares FJ, González-Cano R, Cobos EJ.

Biomed Pharmacother. 2024 Nov;180:117459. doi: 10.1016/j.biopha.2024.117459. Epub 2024 Sep 20.

https://www.sciencedirect.com/science/article/pii/S0753332224013453?via%3Dihub
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